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Онкология

Trapping cancer-driving DNA rings outside cell nucleus silences their genes, researchers find

Cells from rapidly growing, highly metastatic tumors often contain numerous rings of extrachromosomal DNA (ecDNA). This circular DNA frequently carries oncogenes—genes that promote cancer. Researchers have long sought vulnerabilities in these DNA rings in an effort to stop their harmful activity.

Онкология

Methylation test tops 90% sensitivity for BE, 100% for dysplasia

NASHVILLE, Tenn. — A novel DNA methylation test using the EndoSign capsule-sponge detected Barrett’s esophagus with 90% sensitivity and 86% specificity, excelling in longer segments and patients with dysplasia or esophageal adenocarcinoma. Late-breaking clinical trial data presented at ACG Annual Scientific Meeting…