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Онкология

Earlier stem cell transplants may improve survival in rare inherited bone marrow disorder

More than 90% of children born with the rare bone marrow condition Shwachman-Diamond syndrome (SDS) survive beyond age 20. But fewer than 30% live beyond age 50. Long-term survival could improve if clinicians act on early signs of high risk, according to a study published, in The New England Journal of Medicine.

Онкология

Thymus health may impact mortality, cancer outcomes in adults

When Hugo Aerts, PhD, started asking colleagues whether the thymus could play a role in determining which patients with cancer would respond to immunotherapy about 4 years ago, the responses were overwhelmingly dismissive. “It’s irrelevant,” they told him. “[The thymus is] important in kids. Afterwards, it doesn’t…

Онкология

Experimental chemotherapy uses stealth tactic to activate inside cancer cells

Chemotherapy faces a fundamental problem: The same drugs powerful enough to kill cancer cells can also damage healthy tissue. UC Irvine researchers are trying to change that equation by putting a safety lock on a highly potent cancer drug—a lock designed to be removed once the drug enters cancer cells with high levels…

Онкология

Heavily immunosuppressed patients undergoing anticancer immunotherapy face increased risk of severe infections

Immune checkpoint inhibitors (ICIs) can promote antitumor responses but can also cause adverse effects that require treatment with immunosuppressive drugs. A new retrospective study by Mass General Brigham Cancer Institute investigators found that patients who received ICIs and multiple immunosuppressive therapies…